A mouse model of a P. aeruginosa corneal infection showed that treatment with anti-chemokine (C-C motif) ligand 2 (CCL2) or anti-chemokine (C-C motif) ligand 3 (CCL3) antibodies resulted in a significant reduction in the severity of corneal damage and polymorphonuclear neutrophil (PMN) infiltration at 1 and 7 days after infection, without affecting the rate of bacterial clearance from the cornea. This evidence concerns the gene CCL3 and infection.