For assessing the possibility that comorbidities might influence this transcription profile, a further clustering was carried out, considering comorbidities with and without hypertension, as shown in Figure 5B. Notably, TLR2 and TLR4 relative transcript expression was significantly higher in the ERMs from comorbidities without hypertension (+4.198 ± 0.735 FC 2log-ratio for TLR2; +5.331 ± 1.090 FC 2log-ratio for TLR4) and lower in comorbidities with hypertension (−1.869 ± 0.0735 FC 2log-ratio for TLR2; −1.528 ± 0.123 FC 2log-ratio for TLR4). The gene discussed is TLR4; the disease is Hypertension.