Since some in vitro simulations highlighted the ability of TLR2 and TLR4 agonists to trigger the release of IL-6 and MIP-2/C-X-C Motif Chemokine Ligand (CXCL2) chemokines by reactive Müller cells, our observations in ERMs might suggest that TLRs expressing Müller cells can drive immunoregulatory functions in vitreoretinal diseases through DAMP products, in addition to the known role in anti-microbial surveillance (endophthalmitis) [46]. Here, TLR4 is linked to endophthalmitis.