In the present study, LCAA-PSF was found to effectively slow down the inflammatory cytokine secretion of IMQ-induced psoriasis, including the expression of IL-23, IL-17A, TNF-α, and IL-6 in the serum and the expression of IL-17, Ki67, CK5/6 and VEGF in the affected skin area. This evidence concerns the gene TNF and psoriasis.