However, previous studies have shown a significant contribution of macrophages to CNV formation in animal models and AMD patients [124,125,126], and levels of cytokine production and proinflammatory mediators, including TNFα and COX2, were reduced in macrophages isolated from fabp4-deficient (fabp4−/−) mice [127], suggesting that FABP4 may be involved in the pathogenesis of AMD. Here, FABP4 is linked to age-related macular degeneration.