In addition, it has been reported that mice with Sirt1 catalytic activity ablation that were fed a high fat diet (HFD) exhibited an increase in SREBP-1c levels and a decreased phosphorylation of AMPK in the liver, promoting NAFLD [51], which is consistent with the results obtained for SREBP-1c in L12 CAF-fed rats. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatotic liver disease.