In contrast with SGLT2, it has been reported, more than one decade ago, that SGLT1 is expressed in the human heart (10-fold higher than that observed in kidney tissue) [148] and is significantly upregulated in the setting of hypertrophic [46,47] and ischemic cardiomyopathy [48]. The gene discussed is SLC5A1; the disease is ischemic cardiomyopathy.