SLC9A1 and hydrops fetalis: In particular, inhibition by EMPA of the sodium–hydrogen exchanger isoform 1 (NHE1, whose activity increases in the setting of HF) and the underlying signal transduction, have been systematically dissected under various experimental conditions and in different species and reported to be cardioprotective by Coert Zuurbier et al. and others (recently summarized in [114,118]), but not by Michael Shattock et al. [119].