L. casei improves insulin resistance using phosphatidylinositol-3-kinase (PI3K) pathway, the 5′-AMP-Actived Protein Kinase Catalytic Submit-2 (AMPK2), Protein Kinase B (Akt2 o RAC-beta serine/threonine-protein chinase), and controls the synthesis of hepatic glycogen [41]. This evidence concerns the gene AKT2 and Insulin resistance.