Another study has shown that for T2DM mice, supplementing with the Bifidobacterium longum NBM7-1 and Lactiplantibacillus rhamnosus NBM17-4 alleviates glucose intolerance through the upregulation of IL-22, which enhances insulin sensitivity and pancreatic functions while reducing liver steatosis [54]. This evidence concerns the gene INS and Glucose intolerance.