Its role in the ANS has not been elucidated yet, although it has been suggested that the central receptors of asprosin located in the hypothalamic arcuate nucleus may contribute to appetite promotion (and, thus, energy excess and obesity), through the anorexigenic pro-opiomelanocortin (POMC) neurons and the orexigenic agouti-related peptide (AgRP) neurons [87,89,90]. This evidence concerns the gene AGRP and obesity disorder.