The authors found that an increase of HIPK2 protein level in the tumor, compared to the normal mucosa, in univariate analysis, was associated with a better prognosis that did not depend on WTp53 status because it was also observed in p53-mutated background, highlighting the p53-independent function of HIPK2 [61] (Table 1). The gene discussed is HIPK2; the disease is neoplasm.