In vitro studies with colon cancer cells showed that HIPK2 binds, along with HDAC1, to the HIF-1α gene promoter repressing the HIF-1-mediated transcription of VEGF [85], in line with data showing that the HIPK2/HDAC1 complex leads to histone deacetylation and control of gene transcription [45,127]. This evidence concerns the gene HIPK2 and colonic neoplasm.