HIPK2 and malignant colon neoplasm: By using a xenograft colon cancer mouse model, the authors tested the in vivo anti-tumor effect of verbascoside (VB), an active constituent of a Chinese traditional medical plant genus that has an effect in many cancers, including colon cancer [67,68], and measured protein levels of HIPK2 and p53, and the apoptosis-related gene products Bax and Bcl-2.