Thus, HIPK2 knockdown, by using siRNA, in colon cancer cells has been shown to upregulate COX-2 expression and, by using the Oncomine integrated cancer database research tool (http://www.oncomine.org, accessed on 23 June 2024), the analysis of datasets, obtained from specimens of normal tissues and primary colon adenocarcinomas, revealed an inverse correlation between HIPK2 and COX-2 expression [69] (Table 1). The gene discussed is PTGS2; the disease is colon adenocarcinoma.