While pathogenic variants in the PRF1 gene are associated with aplastic anemia, autosomal recessive familial hemophagocytic lymphohistiocytosis, and non-Hodgkin lymphoma, the c.272C>T risk factor variant (rs35947132) was previously also found to be enriched in several different COVID-19 patient cohorts [49,50,51]. This evidence concerns the gene PRF1 and non-Hodgkin lymphoma.