The role for autoantibodies in IAPP clearance was further demonstrated in vivo, showing that exogenous aggregated but not monomeric IAPP evoked autoantibody response in a mouse model of islet amyloidosis, which further prevented IAPP depositions as well as delayed onset of hyperglycemia and the induction of pro-inflammatory IL-1β [21]. This evidence concerns the gene IAPP and Hyperglycemia.