The plasma IAPPO-IgA levels in non-APOE4 carriers correlated positively with plasma levels of IAPP (r = 0.490, p = 0.039), CRP (r = 0.659, p = 0.002), GGT (r = 0.659, p = 0.002), glucose (r = 0.640, p = 0.003), GIP (r = 0.458, p = 0.049), C-peptide (r = 0.516, p = 0.024), insulin (r = 0.458, p = 0.049), and insulin resistance (r = 0.581, p = 0.009) at baseline. This evidence concerns the gene INS and Insulin resistance.