Recently, we have developed a diagnostic treatment algorithm that combines CA125 and BDNF measurements with six pertinent clinical variables: patient’s surgical history related to endometriosis, the manifestation of painful periods as a leading symptom for endometriosis referral, the intensity of menstrual pain during the previous cycle, the age at the onset of intercourse-related pain, the age at the initiation of regular painkiller usage, and the age at the initial diagnosis of an ovarian cyst. This evidence concerns the gene MUC16 and Ovarian cyst.