TYRO3 and precursor B-cell acute lymphoblastic leukemia: Notably, the TAM family members TYRO3 and AXL have also been implicated as potential immune-oncologic targets in acute leukemia [67,69], but the role of each individual TAM RTK may be context-dependent: while whole-body knockout of either Mertk or Tyro3 protected against B-ALL [67], knockout of Axl only prolonged survival if the kinase was selectively deleted in cells expressing the colony-stimulating factor 1 receptor (Csf1r+) [67,69].