Suppression of HMGB3 expression mediated by various small RNAs leads to a decrease in the aggressiveness of prostate cancer cells [193], causes cell death, and inhibits the migration and invasion of breast cancer cells [194,195], colon [196], stomach [177,197], pancreatic duct adenocarcinoma [198], and hepatocellular carcinoma [199]. Here, HMGB3 is linked to Familial prostate cancer.