Suppression of HMGB3 expression, mediated by various small RNAs, leads to a decrease in the aggressiveness of prostate cancer cells [181], causes cell death, and suppresses the migration and invasion of breast [182,183], colon [184], and gastric [149,185] cancer cells, as well as pancreatic ductal adenocarcinoma [186] and hepatocellular carcinoma [187]. Here, HMGB3 is linked to pancreatic ductal adenocarcinoma.