In gastric adenocarcinoma cells, a reduction of HMGB3 expression can dramatically suppress the proliferation of cancer cells, mainly due to the induction of G0/G1 arrest in tumor cells, regulation of p53 and p21 signaling pathways, and the reduction of the level of anti-apoptotic factor Bcl-2/pro-apoptotic factor Bax [151,176]. Here, HMGB3 is linked to cancer.