It is important to note that HMGB3 is an oncogene that promotes, through various mechanisms, initiation, development, and resistance to chemotherapy in breast cancer [210], colorectal cancer [81], thyroid cancer [91], neuroblastoma [246], nasopharyngeal carcinoma [247], and cervical cancer [179]. The gene discussed is HMGB3; the disease is thyroid gland carcinoma.