IL-8 binds with high affinity to the G protein-coupled receptors CXCR1 and CXCR2, and the Duffy antigen receptor for cytokines, CXCR1, formerly known as the IL-8 type A receptor, which responds to high concentrations of IL-8, is most often found at sites of infection. The gene discussed is CXCL8; the disease is infection.