In contrast, the IPP network of TAB2 and SOX9 and the IPP network of CIITA promote the inflammatory response in the brain, since NF-κB (activated by the MAP3K7/TAK1/TAB2/TAB3/TAB2/TAB3 complex) promotes the inflammatory response in the brain and the transcription of coding genes for inflammatory cytokines (such as IL-1β, IL-6, IL-12, and TNF [50]) and SOX9, which could play an important role in the activation of astrocytes and release of chondroitin sulfate pro-teoglycans that contribute to glial scar formation in AD individuals [51]. Here, TNF is linked to Alzheimer disease.