When STRING V11.5 (https://string-db.org/; accessed on 5 July 2023) was used with all proteins coded by the 18 lncRNA-associated genes, we found statistically significance evidence (P < 0.05 and an average clustering coefficient [ACC] > 0.7), as well as enrichment in biological pathways and molecular functions related to AD in the PPI of proteins PMM2, PROX1, SNX8, SMAD2, GAS6, POT1, SRCIN1, CIITA, SS18, ABI2, TAB2, RPGR, RBL2, HTR2A, and SOX9. This evidence concerns the gene SMAD2 and Alzheimer disease.