TBL1XR1 and Familial prostate cancer: For example, TBL1XR1, one of the significantly up-regulated E3 across 12 cancer types, has been reported to be associated with the progression and clinical prognosis of various human malignancies, such as human non-small cell lung cancer [12] prostate cancer [13], extranodal lymphoma [14], and gastric cancer [15].