TNF and obesity due to melanocortin 4 receptor deficiency: It has a pro-inflammatory effect, augmenting the expression of cytokines like interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α/TNF-alpha) in the adipose tissue [12], being involved in the development and the persistency of an inflammatory status in obesity, type 2 diabetes mellitus [13], metabolic syndrome [13], cardiovascular diseases [14,15], and sepsis [12].