Low-density lipoprotein receptor-related protein 1 (LRP-1) and amyloid-β (Aβ) levels in the liver tissue of rats [24] and mice [25] with NAFLD were reduced; these decreases correlated inversely with Aβ levels in the brain and plasma as well as cognitive function. This evidence concerns the gene LRP1 and metabolic dysfunction-associated steatotic liver disease.