RUNX3 and neoplasm: Promoter hypermethylation leading to decreased protein levels has also been documented in EAOC for several other tumor suppressor genes encoding Runt-related transcription factor 3 (RUNX3) [18], E-cadherin (CDH1) [20], the Ras-association domain family of gene 2 (RASSF2) [21], and CDKN2A/p16 [149,153].