PTEN and endometriosis: Candidate gene mapping and linkage studies were the first to implicate tumor suppressor genes in endometriosis: loss of heterozygosity (LOH) was detected in genes encoding phosphatase and tensin homolog deleted on chromosome 10 (PTEN) [111], tumor protein p53 (TP53), and AT-rich interactive domain-containing protein 1 (ARID1) [112].