Amin et al., in their necropsy casework study in which they also compared the immunohistochemical expression of MB in cases with definite signs of ischemia, cases with probable signs of ischemia, and cases without signs of ischemia but with other causes of myocardial damage, found variable myoglobin depletion in all cases with definite signs of ischemia and in all cases with other causes of myocardial damage [44]. The gene discussed is MB; the disease is ischemia.