Among many proteins demonstrated to differ in terms of expression between non-tumor and tumor samples, McKinney et al. analyzed biglycan (BGN), pigment epithelium-derived factor (PEDF), thrombospondin-2 (THBS-2), and TGF-β induced protein ig-h3 precursor (βIGH3) as potential minimally invasive diagnostic markers for their effect in cancer when up-regulated [45]. The gene discussed is BGN; the disease is neoplasm.