Papapanagiotou et al. recently investigated the role of secreted protein acidic and rich in cysteine (SPARC) and osteonectin in various processes during the development of pancreatic adenocarcinoma, showing a sensitivity of 84.6% and a specificity of 87.5% for the detection of early-stage PDAC [37]. The gene discussed is SPARC; the disease is pancreatic adenocarcinoma.