GRK2 and atrial fibrillation: Future investigations with multiple test groups incorporating varying durations of SD (including short-term, prolonged, partial, and total SD) and employing cardiac-specific GRK2 overexpression models in rats could offer a dose–response relationship between SD and AF genesis and provide a more precise understanding of the pathological roles of GRK2 and calcium-handling proteins in SD-induced atrial arrhythmogenesis.