CXCR4 and acute myeloid leukemia: Studies using primary acute myeloid leukaemia blasts and in vitro cell lines have further elucidated that Pim kinase inhibition using pharmacological inhibitors also downregulates CXCR4 on the cell surface, which leads to a reduction in CXCL12/CXCR4 signalling and cell migration [28,29].