AKT1 and escherichia coli infection: Figure 5D shows that intersecting 125 pathways enriched by network pharmacology with 20 pathways enriched by transcriptome sequencing yielded a total of 8 pathways, i.e., the PI3K-AKT signaling pathway, proteoglycans in cancer, parathyroid hormone synthesis, secretion and action, fluid shear stress and atherosclerosis, diabetic cardiomyopathy, lipid and atherosclerosis, platelet activation, and pathogenic Escherichia coli infection.