As depicted in Figure 6B, SLC1A5 knockdown significantly decreased 3H-glutamine uptake in all studied conditions, regardless of glutamine addition, presence of glucose, or inhibition with GPNA, in both Huh7 (0, 0.25, and 4 mM gln: p < 0.05; DMEMc: p < 0.0001; GPNA: p < 0.001) and Hep3B (all p < 0.05) HCC cells. Here, SLC1A5 is linked to hepatocellular carcinoma.