We focused on the amino acid transporters SLC1A5, SLC6A14, SLC7A6, SLC38A1, SLC38A2, SLC38A3, and SLC38A5 by investigating their transcriptional expression profiles in HCC, their role in cellular glutamine transport function, as well as their clinical significance in HCC patients. This evidence concerns the gene SLC38A5 and hepatocellular carcinoma.