As shown in Figure 6H, combined siRNA inhibition of SLC1A5 and SLC38A2 had the most considerable negative impact on 3H-glutamine uptake in HCC cells, decreasing uptake capacities in all conditions by nearly half in Huh7 cells (0, 0.25 mM gln: p < 0.001; 4 mM gln, GPNA: p < 0.01; DMEMc: p < 0.05), similarly to what was observed in Hep3B cells (0, 0.25, 4 mM gln: p < 0.05; DMEMc, GPNA: p < 0.001). The gene discussed is SLC38A2; the disease is hepatocellular carcinoma.