WDR45 and Global developmental delay: Moreover, in the proband’s eldest daughter, affected with developmental delay and facial abnormalities, we found an in-frame deletion NM_007075.3:c.752_754delCCT (p.Ser251del) in the WDR45 gene, previously described in connection to beta-propeller protein-associated neurodegeneration—a rare form of neurodegeneration with brain iron accumulation [22,23].