SNCA and Parkinson disease: In PD, curcumin promotes autophagy through interference with alpha-synuclein aggregation and stimulates proteins like LC3-II which is a standard marker for autophagosomes, transcription factor EB which is a key nuclear transcription factor in control of autophagy, and lysosomal-associated membrane protein 2 isoform A (LAMP2A) which is the key component of chaperone-mediated autophagy to induce neuroprotection and prevention [356].