CX3CL1 and type 2 diabetes mellitus: Although patients with T2D usually have higher plasma concentrations of CX3CL1 than healthy individuals, due to general pro-inflammatory phenotypes related to a high-carbohydrate hypercaloric diet, there are no research studies that allow verifying if this peripheral CX3CL1 acts on the CNS and thus makes any difference in reference to the course of DE [156].