Evidence from a case series of infertile women affected by hypothalamic amenorrhea (HA) who presented for fertility treatment with very low functional ovarian reserve shows that the administration of LH (at least 150–187.5 IU/day or every other day) may contribute to a clinically evident increase from baseline in both functional ovarian reserve (AFC) and AMH, and probably accounts for a positive effect of LH on the progression of small growing follicles through the antral stage [45]. The gene discussed is PLOD1; the disease is Infertility.