PLOD1 and polycystic ovary syndrome: In PCOS patients, variants of LH receptor (LHR) have been found; these LHR variants may diminish or enhance pituitary LH stimulation of ovarian theca and stroma cell T production, ovarian follicle development, LH-surge-induced ovulation and corpus luteum function, contributing to the genetic determination of PCOS phenotypes with specific reproductive pathophysiology [10].