In addition, circMYBL2 (derived from the cell cycle checkpoint gene MYBL2) facilitates protein translation and exacerbates acute myeloid leukemia by enhancing the interaction between polypyrimidine tract-binding protein 1 (PTBP1) and FMS-like tyrosine kinase 3 (FLT3) mRNA [121]. The gene discussed is PTBP1; the disease is acute myeloid leukemia.