LZTR1 and cancer: However, due to the higher risk of cancer in NS, the reported LZTR1 somatic mutations in breast cancer (COSMIC database, http://www.sanger.ac.uk/cosmic, accessed on 8 July 2024), and the reported association between LZTR1 and breast cancer in a recent study [56,57], we cannot completely exclude a LZTR1-related increase in cancer risk.