Germline LZTR1 variants are reported in Noonan syndrome, which can be either autosomal dominant (Noonan syndrome 10, #MIM 616564) or autosomal recessive (Noonan syndrome 2, #MIM 605275), and are also associated with susceptibility to schwannomatosis (#MIM 615670). This evidence concerns the gene LZTR1 and schwannomatosis.