The NGS analysis using a panel including genes associated with hereditary breast and ovarian cancers (SOPHiA HEREDITARY CANCER SOLUTIONTM kit, including the following genes: ABRAXAS1, ATM, APC, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PIK3CA, PMS2, PMS2CL(1), PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, and XRCC2) resulted non-informative; neither pathogenic/probably pathogenic nor unknown significance variants were identified. This evidence concerns the gene MLH1 and neoplasm.