lncRNA XIST promotes brown preadipocyte differentiation and combats high-fat-diet-induced obesity by directly binding to C/EBPα, as demonstrated through the RNA- binding protein immunoprecipitation (RIP) experiment, indicating that lncRNA XIST is at least partially involved in the differentiation of brown adipocytes by binding to C/EBPα. This evidence concerns the gene CEBPA and obesity due to melanocortin 4 receptor deficiency.