Although most studies found an association between rs2236225 and CHD, some smaller case-control studies did not find a statistically significant difference between cases and controls in the frequency of the variant allele [42,47,61,62] Finally, in the Hispanic population in the USA, the MTHFD1 variant rs11627387 (Table 6) was associated with an increased risk of conotruncal CHD [57]. This evidence concerns the gene MTHFD1 and coronary artery disorder.