We again find several sites located in genes that are known to be cancer-related, such as cathepsin S (CTSS), protein kinase C substrate 80K-H (PRKCSH), serine/threonine kinase 4 (STK4), antizyme inhibitor 1 (AZIN1), NOP14 nucleolar protein (NOP14), von Hippel–Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) and tumor protein p53 (TP53). The gene discussed is UBE2E3; the disease is cancer.