Moreover, we note that several differentially edited sites are located in genes that are known to be cancer-related (Table 1), such as cathepsin S (CTSS), cathepsin B (CTSB) and protein kinase C substrate 80K-H (PRKCSH), NOP14 nucleolar protein (NOP14), serine/threonine kinase 4 (STK4), von Hippel–Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL), and SAM domain and HD domain 1 (SAMHD1). The gene discussed is UBE2E3; the disease is cancer.