Similarly, genetic tumor syndromes and familial AML and myelodysplastic syndromes may manifest with disease in the pediatric or adult ages, with some age predilections such as germline GATA2, SAMD9, and SAMD9L abnormalities often being identified in myeloid neoplasms presenting in the pediatric age group, and germline DDX41 also presenting in older adults. This evidence concerns the gene SAMD9L and myelodysplastic syndrome.