For the subgroup of 69 patients who presented thyroid nodules in the US and had a previous history of thyroid disease, a review of pathogenic germline variants showed that most of them (25 patients, 36% of total) were carriers of an MSH6 germline mutation, while 22 (32%), 17 (24%), and 5 (7%) had MSH2, MLH1, and PMS2 mutations, respectively. Here, MSH6 is linked to thyroid nodule.