MAP3K1 and disorder of sexual differentiation: Nearly all the DSD-associated MAP3K1 variants are clustered in the N-terminal Guanine Exchange Factor (GEF), SWI2/SNF2 and MuDR (SWIM), RING finger including a PHD motif (RING/PHD), and armadillo repeats (ARM)/tumor overexpressed gene (TOG) domains (Figure S4 and Table S3).