MAP3K1 and disorder of sexual differentiation: However, we stress that the predicted minor but deleterious alteration in the local structure due to the p.(Arg1487His) substitution was expected and is consistent with the limited phenotype of nonsyndromic deafness DFNB128 in comparison to the severe pleiotropic phenotype of the two reported highly damaging alleles of mouse Map3k1 [5,6] and with the complex DSD phenotype due to dominant variants of MAP3K1 [17,18,19,20].