MLH1 and colorectal carcinoma: Several markers associated with CRC, such as MutL homolog 1 (Mlh1, a mismatch repair (MMR) gene), a disintegrin and metalloproteinase with thrombospondin motif 1 (Adamts1, an anti-angiogenic gene), myelin and lymphocyte (Mal, a T-cell differentiation gene), and O-6-methylguanine-DNA methyltransferase (Mgmt), exhibit hypermethylation in their promoter regions [4,5,6,7].