GATA1 and Diamond-Blackfan anemia: Thus, in a non-exclusive manner, it has been proposed that (i) the hypo-proliferative, pro-apoptotic anemia associated with DBA could be the consequence of a global reduction in translation, limiting below a critical threshold the synthesis of critical proteins, such as the globins and the transcription factor GATA1, with the latter being essential for normal erythropoiesis [218].