TCN1 and Diamond-Blackfan anemia: From a very simplistic point of view, as the DBA disease is mostly caused by loss-of-function mutations in several r-protein and a few RAF genes, all associated DBA symptoms and manifestations must come from common dysfunctions of the same molecular process that, in this case, can be no other than ribosome biogenesis [217], ultimately leading to an impairment or a limitation of translation.