Mutations and altered expression of beak r-proteins have been described in many cancer types, in some cases likely displaying an extra-ribosomal function: (i) high expression of RPS10 has been found in colorectal, renal and prostate cancer [240], whereas it has been reported that ribosomes purified from MDA-MB-231 breast cancer cells contain substoichiometric levels of eS10, among other r-proteins [119]. This evidence concerns the gene RPS10 and Familial prostate cancer.