Mutations and altered expression of beak r-proteins have been described in many cancer types, in some cases likely displaying an extra-ribosomal function: (i) high expression of RPS10 has been found in colorectal, renal and prostate cancer [240], whereas it has been reported that ribosomes purified from MDA-MB-231 breast cancer cells contain substoichiometric levels of eS10, among other r-proteins [119]. The gene discussed is TCN1; the disease is breast cancer.