PKM and hepatocellular carcinoma: E3 ubiquitin ligase zinc finger protein 91 promotes Lys48-linked ubiquitination and proteasomal degradation of HNRNPA1 at Lys8, inhibiting HNRNPA1-dependent PKM alternative splicing, shifting toward higher PKM1 and lower PKM2 subtypes, and suppressing HCC glucose metabolism reprogramming, cell proliferation, and metastasis [255].