SOD1 and amyotrophic lateral sclerosis: Activation of P2XR7 through intramuscular administration of the P2XR7 agonist 2′(3′)-O-(4-benzoylbenzoyl) adenosine 5-triphosphate (BzATP) into the tibialis anterior (TA), gastrocnemius medialis (GCM), and quadriceps (QC) of SOD1 (G93A) mice enhances the pro-regenerative activity of infiltrating macrophages and improves the motor performance of ALS mice by promoting the activation and differentiation of MuSCs [40].