IL1B and amyotrophic lateral sclerosis: Investigations into therapeutic interventions for sporadic ALS patients revealed that dimethyl fumarate (DMF) and the cGAS/STING pathway inhibitor H-151 downregulate granzymes and pro-inflammatory cytokines (IL-1β, IL-6, IL-15, IL-23A, IFN-γ), promoting a pro-resolution macrophage phenotype.