Research has demonstrated a higher TRPM8 mRNA expression in human esophageal cancer tissues compared to adjacent tissues and an elevation in human esophageal cancer cell lines compared to normal esophageal epithelial cells, with the knockdown or inhibition of TRPM8 resulting in a reduced cancer cell proliferation, while the overexpression of TRPM8 had the opposite effect. Here, TRPM8 is linked to cancer.