PTGS2 and erythema multiforme: Other studies have highlighted the contribution of elevated levels of inflammatory mediators, hormones, and immune cells as cyclooxygenase-2, interleukin-β, interleukin-6, IL-8, tumor necrosis factor alpha, prostaglandin E2, and estradiol in the tissue microenvironment and the peritoneal fluid of patients with EM in the survival, implantation, invasion, growth, angiogenesis, immunosurveillance evasion, and establishment of endometriotic lesions [10,45,48,49,50,51].