CASP3 and neurodegenerative disease: In order to study the potential antiapoptotic effects of our incretin-based multi-agonists, we employed STS, a compound known to initiate apoptosis via caspase-3-dependent and -independent mechanisms [57], in human neuronal SH-SY5Y cells to simulate pro-apoptotic and neurotoxic conditions of the neurodegenerative disease brain.