Indeed, we found that insulin-dependent neuroprotection from cell death during neuronal ischemia is associated with the expression and function of DMT1, previously described as epigenetically regulated by NFkB, and the major ferrous iron transporter with a maximum uptake in acidic conditions as a proton co-transporter, particularly active during the extracellular acidosis present during ischemia. This evidence concerns the gene SLC11A2 and ischemia.