Accordingly, the NF-kB-dependent role of DMT1 has been previously addressed in the early phase of post-ischemic neurodegeneration, in both differentiated human neuroblastoma cells (SK-N-SH) and primary cortical neurons exposed to OGD, and in the in vivo mice model of transient middle cerebral artery occlusion (tMCAO). This evidence concerns the gene SLC11A2 and neuroblastoma.