NFKB1 and neurodegenerative disease: Thus, it is worth mentioning that DMT1, responsible for NTBI, is known to be up-regulated through NF-kB-mediated epigenetic regulation in the aforementioned neurodegenerative diseases [8,9,10,11] and in neurodegeneration with brain iron accumulation (NBIA/BPAN), with the altered intracellular transport of iron and heavy metals found in primary fibroblasts of affected patients [5,25].