Interestingly, in this relationship, it has previously been shown that DMT1 over-expression in SK-N-SH human neuroblastoma cells leads to an increase in both cell death and intracellular iron content, while the knockdown of (−)IRE/DMT1 by siRNA completely prevented both iron uptake and cell death [11]. The gene discussed is SLC11A2; the disease is neuroblastoma.