In this relationship, we here evaluated the effectiveness of insulin treatment in the protection by neuronal ischemic-dependent cell death with the contribution of DMT1 as a molecular target in both differentiated human neuroblastoma cells, SK-N-SH, and primary mouse cortical neurons, after 8 and 3 h of OGD, respectively (Figure 1A,E), where we found DMT1 down-regulation, after acute insulin treatment, at the protein level, in differentiated SK-N-SH after 8 h OGD compared to control OGD (Figure 1B,C) with significant neuroprotection against cell death during OGD (Figure 1A). Here, SLC11A2 is linked to neuroblastoma.