Furthermore, the NFκB-mediated epigenetic up-regulation of DMT1 was shown in the early phase of ischemic neurodegeneration, with ferrous iron and 1B/(−)IRE DMT1 accumulation found in the model of post-ischemic neurodegeneration during in vitro ischemia induced by oxygen–glucose deprivation (OGD) in primary mouse cortical neurons and the neuronally differentiated human neuroblastoma cells, SK-N-SH, where 1A/DMT1 showed no prevalent expression, with the up-regulation of the 1B/(−)IRE DMT1 protein and mRNA, also in mice subjected to transient middle cerebral artery occlusion (MCAO) [11]. This evidence concerns the gene SLC11A2 and neuroblastoma.