In the study by Adams et al., while total BA concentrations were associated with liver fibrosis severity in patients with SLD, after adjusting for potential confounding factors (age, sex, body mass index (BMI), hypertension, type 2 diabetes, total cholesterol, homeostatic model assessment for insulin resistance (HOMA-IR), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TAG)), only GCA, GCDCA, and GDCA concentrations were higher in patients with SLD with more (F3/F4) vs. less (F0–2) severe liver fibrosis [20]. The gene discussed is GNAT3; the disease is Hepatic fibrosis.