IL4 and melanoma: M0 macrophages treated with EVs alter their phenotypes, especially with HLADR and CD163; we found that CD163 and HLADR populations were increased after challenging with EVs, and HLADR+CD163+ cells were detected in the patient or melanoma-cell-line-EV-challenged cells, as well as IL4-treated M0 macrophages (Figure 3B).