TNF and metabolic syndrome: Notably, in a clinical trial with 97 elderly patients with T2DM, it was shown that resveratrol treatment reduced HbA1c levels, CRP, and lipoperoxide values [217], while a combined treatment with resveratrol and delta-tocotrienol in 82 patients with metabolic syndrome reduced fasting plasma glucose, CRP, IL-6, and TNF-α levels [218].