INS and type 2 diabetes mellitus: These authors reported on the biological activities of polyphenols concerning the protection of pancreatic islet β-cells, the antioxidant capacities of these bioactives, the effects on insulin secretion, the regulation of intestinal microbiota [36], and the effects of a diet rich in polyphenols in a cohort of 7000 participants, indicating that a high plant-based diet index (PDI) can be recommended to reduce the risk of T2DM development [37].