Interestingly, it has been shown that the combination of curcumin, polydatin, quercetin, naringenin, and hesperetin present in the nutraceutical GliceFen® (Mivell, Fano, Italy) was able to synergistically and significantly decrease the expression levels of the pro-inflammatory gene Semaphorin 3E (SEMA3E), which is also involved in the mechanisms of insulin resistance through the inhibition of Akt phosphorylation [4,121]. Here, SEMA3E is linked to Insulin resistance.