To this end, the important role that isorhamnetin plays in lowering glucose concentrations by increasing GLUT4 levels, improving oxidative status through the increase in Nrf2, SOD, and CAT levels, reducing inflammation by decreasing NF-kB, and adjusting lipid metabolism in both in vitro and in vivo models suggests that isorhamnetin may be used for the treatment of T2DM [97]. This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.