CASP1 and osteoporosis: Notably, the consumption of nutraceuticals containing different antioxidant and anti-inflammatory polyphenols could be an adjuvant supplement to counteract the hyperglycemia condition of T2DM and to reduce the levels of specific pro-inflammatory interleukins, such as IL-1β, which is activated by Caspase 1 in the inflammasome complex and contributes to the development of osteoporosis pathology and also to endothelium damage in T2DM (Figure 3) [3,230].