Considering this scientific evidence, the polyphenols that can increase GLUT4 and INSR levels, activate the IRS/PI3K/Akt molecular pathway, and inhibit the molecular mechanisms of oxidative stress through the activation of antioxidant cellular defenses can inhibit T2DM development and the onset of complications related to diabetes, such as blood vessel destruction, damage to the heart, eyes, kidneys, and central nervous system [81,82]. The gene discussed is INSR; the disease is type 2 diabetes mellitus.