CYP27A1 and osteoporosis: Notably, it has been shown that the polyphenol icariin, in an in vivo experimental model of diabetic osteoporosis, reduced blood glucose levels, increased the BMD of diabetic rats, and decreased the levels of the bone resorption markers CTX and TRACP 5b, indicating that this polyphenol can target a molecular network that regulates the development of both T2DM and osteoporosis [234].