Considering this scientific evidence, the polyphenols that can increase Runx2, ALP, OCN, and OSX levels and counteract the ability of senescent BM-MSCs to release those cytokines and interleukins that can transform the young BM-MSCs into senescent BM-MSCs, play a pivotal role in counteracting osteoporosis development and in avoiding the depletion of the cell population of young BM-MSCs, which can differentiate into new osteoblasts and induce the formation of new bone tissue [5]. The gene discussed is RUNX2; the disease is osteoporosis.