TNF and type 2 diabetes mellitus: Particularly, in a clinical trial with 50 T2DM patients treated with rutin, there was a decrease in IL-6 and HbA1c levels and an increase in total antioxidant capacity [219], while in a dietary intervention among 31 patients with T2DM, a 6-week daily intake of 500 mg of hesperetin significantly decreased the levels of the inflammatory markers CRP and TNF-α and increased the serum total antioxidant capacity [220].